Phospholipase D is an enzyme that is involved in the cleavage of phospholipids, specifically targeting the phosphodiester bond in the lipid bilayer. This enzyme plays a crucial role in regulating various cellular processes, including signal transduction, membrane trafficking, and cell proliferation. Dysregulation of phospholipase D activity has been linked to several diseases, such as cancer, neurodegenerative disorders, and inflammatory conditions. Research in the area of phospholipase D focuses on understanding the biochemical and physiological functions of this enzyme, as well as developing potential therapeutic strategies to target it for the treatment of various diseases.